2019/04/11

 

CRISPR Computer in Human Cells

A CRISPR/Cas9-based core processor that enables different sets of user-defined guide RNA inputs to program a single transcriptional regulator (dCas9-KRAB) to perform a wide range of bitwise computations, from simple Boolean logic gates to arithmetic operations such as the half adder. [...] In principle, human cells integrating multiple orthogonal CRISPR/Cas9-based core processors could offer enormous computational capacity. Full article @ PNAS

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